Incorporation of Heterocycles into Combinatorial Chemistry by Eugene V. Babaev

By Eugene V. Babaev

the writer has summarized a decade of educating combinatorial chemistry into this well timed short. the forged section synthesis of unnatural heterocyclic alpha-amino acids is illustrated by means of sensible examples ranging from the ABCs of peptide synthesis explored in bankruptcy one. Chapter is anxious with the forged section synthesis that is proven on numerous concepts – BillBoard, tea-bag, and Lantern units, and verified on heterocyclic examples and protocols. within the 3rd bankruptcy the instruments for accelerating chemical synthesis – good part and liquid section – are reviewed. right here the thoughts of parallel refluxing (including microwave and move strategy) and parallel separation (filtration, centrifugation, evaporation, and chromatography) are defined. within the chapters four and five the writer is going directly to describe how the liquid section synthesis of heterocycles (reductive amination and Ugi response of heterocycles) is illustrated with using semi-automated protocols. ultimately, the layout of combinatorial libraries of heterocycles is reviewed together with the unique author’s findings.

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